RESUMO
Although the quantification of protein excretion is valuable for diagnosing and monitoring renal disease, accurate, timed, urine collection entails practical difficulties in children. Several authors have shown that the random urine protein/creatinine ratio (UP/UC) correlates well with timed protein excretion. A novel dipstick, Multistix PRO, has recently enabled us to analyze concentrations of both urinary protein and creatinine, semi-quantitatively, in 60 s. The aim of this study was to investigate whether the UP/UC values obtained by Multistix PRO correlate well with those obtained by quantitative methods and daily urinary protein excretion. In order to obtain the UP/UC values, we measured urinary protein and creatinine concentrations both semi-quantitatively by Multistix PRO and quantitatively by conventional methods. The relationship between the semi-quantitative UP/UC by Multistix PRO and the quantitative UP/UC by conventional methods was analyzed. Similarly, the relationship between the semi-quantitative UP/UC and daily urinary protein excretion was studied. Semi-quantitative UP/UC by Multistix PRO correlated closely with both quantitative UP/UC and daily urinary protein excretion (r=0.86 and r=0.91, respectively). A cut-off level of heavy proteinuria, i.e., nephrotic range of proteinuria (>3.5 g/day) corresponded to 3.0, assessed by UP/UC by Multistix PRO. The semi-quantitative UP/UC by Multistix PRO correlated well with both quantitative UP/UC and daily urinary protein excretion, and use of the Multistix PRO would avoid errors and difficulties associated with timed urine collection. It is, therefore, a useful tool to monitor the urinary protein excretion in children with renal diseases at outpatient clinic.
Assuntos
Proteinúria/diagnóstico , Fitas Reagentes , Adolescente , Adulto , Criança , Pré-Escolar , Creatinina/urina , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Concentração Osmolar , Fatores de TempoAssuntos
Transplante de Células-Tronco de Sangue do Cordão Umbilical , Infecções por Citomegalovirus/sangue , Síndrome de DiGeorge/complicações , Síndrome de DiGeorge/terapia , Carga Viral , Antígenos Virais/sangue , Antígenos Virais/urina , Citomegalovirus/isolamento & purificação , Infecções por Citomegalovirus/complicações , Infecções por Citomegalovirus/imunologia , DNA Viral/sangue , DNA Viral/urina , Síndrome de DiGeorge/diagnóstico , Síndrome de DiGeorge/imunologia , Humanos , Hospedeiro Imunocomprometido , Lactente , Masculino , Linfócitos T/imunologiaAssuntos
Ciclosporina/uso terapêutico , Vasculite por IgA/complicações , Imunossupressores/uso terapêutico , Síndrome Nefrótica/tratamento farmacológico , Criança , Resistência a Medicamentos , Glucocorticoides/farmacologia , Glucocorticoides/uso terapêutico , Humanos , Masculino , Metilprednisolona/farmacologia , Metilprednisolona/uso terapêutico , Síndrome Nefrótica/etiologiaRESUMO
UNLABELLED: We report the unusual case of a 2-month-old boy with systemic fibromuscular dysplasia (FMD). He presented with congenital renovascular hypertension due to stenosis of the right renal artery, and later developed renal infarction on the contralateral side resulting in renal failure. The boy subsequently died of intracranial haemorrhage at the age of 14 months. During the course, hemiconvulsion caused by a Moyamoya disease-like vascular lesion was noted. Stenotic lesions of both the abdominal aorta and its branches were also revealed by angiography. Post-mortem examination confirmed that the coronary, splenic and mesenteric arteries were also affected and their histological findings were compatible with FMD. To our knowledge, this is the first congenital case of FMD demonstrating a rapidly progressive course resulting in a fatal outcome. In this case, multivessels in both intracranial and extracranial arteries were involved. CONCLUSION: Our case suggests that the nature of fibromuscular dysplasia is congenital in origin and its aetiology, at least in some cases, is a systemic abnormality of vascular development.